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In accordance with the imaging mass spectrometry results, GSH and GSSG levels were significantly elevated in kidneys with TLS, accompanied by an increased GSSG/GSH ratio (Figure 1J)

Lilly is also awaiting a decision from the FDA on a filing for orforglipron sometime in early 2026, though a Commissioners National Priority Voucher could move up that timeline.

IPCE Credit : UCSF Office of CME designates this Live Activity for a maximum of 16.50 Interprofessional Continuing Education (IPCE) Credit(s)

The peptides have short plasma half-lives (under 30 minutes), requiring consistent daily dosing to maintain therapeutic CNS concentrations